Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy

Chemotherapy-induced peripheral neuropathy (CIPN) arises from collateral damage to peripheral afferent sensory neurons by anticancer pharmacotherapy, leading to debilitating neuropathic pain. No effective treatment for CIPN exists, short of dose-reduction which worsens cancer prognosis. Here, we rep...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: LoCoco, Peter M, Risinger, April L, Smith, Hudson R, Chavera, Teresa S, Berg, Kelly A, Clarke, William P
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701795/
https://ncbi.nlm.nih.gov/pubmed/29125463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29626
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