Induced Pluripotent Stem Cell-Derived Neural Stem Cell Transplantations Reduced Behavioral Deficits and Ameliorated Neuropathological Changes in YAC128 Mouse Model of Huntington's Disease

Huntington's disease (HD) is a genetic neurodegenerative disorder characterized by neuronal loss and motor dysfunction. Although there is no effective treatment, stem cell transplantation offers a promising therapeutic strategy, but the safety and efficacy of this approach needs to be optimized...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Al-Gharaibeh, Abeer, Culver, Rebecca, Stewart, Andrew N., Srinageshwar, Bhairavi, Spelde, Kristin, Frollo, Laura, Kolli, Nivya, Story, Darren, Paladugu, Leela, Anwar, Sarah, Crane, Andrew, Wyse, Robert, Maiti, Panchanan, Dunbar, Gary L., Rossignol, Julien
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701605/
https://ncbi.nlm.nih.gov/pubmed/29209158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2017.00628
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