Study protocol: A multi-centre, double blind, randomised, placebo-controlled, parallel group, phase II trial (RIDD) to determine the efficacy of intra-nodular injection of anti-TNF to control disease progression in early Dupuytren’s disease, with an embedded dose response study.

Dupuytren’s disease is a common fibrotic condition of the hand affecting 4% of the population and causes the fingers to curl irreversibly into the palm. It has a strong familial tendency, there is no approved treatment for early stage disease, and patients with established digital contractures are m...

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Detalhes bibliográficos
Publicado no:Wellcome Open Res
Main Authors: Nanchahal, Jagdeep, Ball, Catherine, Swettenham, Jennifer, Dutton, Susan, Barber, Vicki, Black, Joanna, Copsey, Bethan, Dritsaki, Melina, Taylor, Peter, Gray, Alastair, Feldmann, Marc, Lamb, Sarah
Formato: Artigo
Idioma:Inglês
Publicado em: F1000 Research Limited 2017
Assuntos:
Study Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701439/
https://ncbi.nlm.nih.gov/pubmed/29218326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/wellcomeopenres.11466.2
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