Midkine derived from cancer-associated fibroblasts promotes cisplatin-resistance via up-regulation of the expression of lncRNA ANRIL in tumour cells

Midkine (MK) is a heparin-binding growth factor that promotes carcinogenesis and chemoresistance. The tumour microenvironment (TME) can affect chemotherapy sensitivity. However, the role of stromal-derived MK, especially in cancer-associated fibroblasts (CAFs), is unclear. Here, we confirmed that MK...

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Vydáno v:Sci Rep
Hlavní autoři: Zhang, Dongya, Ding, Liang, Li, Yi, Ren, Jing, Shi, Guoping, Wang, Yong, Zhao, Shuli, Ni, Yanhong, Hou, Yayi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701200/
https://ncbi.nlm.nih.gov/pubmed/29176691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13431-y
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