Yüklüyor......

Towards personalised allele-specific CRISPR gene editing to treat autosomal dominant disorders

CRISPR/Cas9 holds immense potential to treat a range of genetic disorders. Allele-specific gene disruption induced by non-homologous end-joining (NHEJ) DNA repair offers a potential treatment option for autosomal dominant disease. Here, we successfully delivered a plasmid encoding S. pyogenes Cas9 a...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Christie, Kathleen A., Courtney, David G., DeDionisio, Larry A., Shern, Connie Chao, De Majumdar, Shyamasree, Mairs, Laura C., Nesbit, M. Andrew, Moore, C. B. Tara
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2017
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701044/
https://ncbi.nlm.nih.gov/pubmed/29170458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16279-4
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!