A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells

Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg) cells. The mouse parasite Heligmosomoides polygyrus can expand the host Treg population by secreting products that activate TGF-β signalling, but the...

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Publicado no:Nat Commun
Main Authors: Johnston, Chris J. C., Smyth, Danielle J., Kodali, Ravindra B., White, Madeleine P. J., Harcus, Yvonne, Filbey, Kara J., Hewitson, James P., Hinck, Cynthia S., Ivens, Alasdair, Kemter, Andrea M., Kildemoes, Anna O., Le Bihan, Thierry, Soares, Dinesh C., Anderton, Stephen M., Brenn, Thomas, Wigmore, Stephen J., Woodcock, Hannah V., Chambers, Rachel C., Hinck, Andrew P., McSorley, Henry J., Maizels, Rick M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701006/
https://ncbi.nlm.nih.gov/pubmed/29170498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01886-6
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