Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function

The co-chaperone FKBP5 is a stress-responsive protein-regulating stress reactivity, and its genetic variants are associated with T2D related traits and other stress-related disorders. Here we show that FKBP51 plays a role in energy and glucose homeostasis. Fkbp5 knockout (51KO) mice are protected fr...

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Publicado no:Nat Commun
Main Authors: Balsevich, Georgia, Häusl, Alexander S., Meyer, Carola W., Karamihalev, Stoyo, Feng, Xixi, Pöhlmann, Max L., Dournes, Carine, Uribe-Marino, Andres, Santarelli, Sara, Labermaier, Christiana, Hafner, Kathrin, Mao, Tianqi, Breitsamer, Michaela, Theodoropoulou, Marily, Namendorf, Christian, Uhr, Manfred, Paez-Pereda, Marcelo, Winter, Gerhard, Hausch, Felix, Chen, Alon, Tschöp, Matthias H., Rein, Theo, Gassen, Nils C., Schmidt, Mathias V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700978/
https://ncbi.nlm.nih.gov/pubmed/29170369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01783-y
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