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Combinatorial CRISPR-Cas9 and RNA Interference Attack on HIV-1 DNA and RNA Can Lead to Cross-Resistance

Many potent antiviral drugs have been developed against HIV-1, and their combined action is usually successful in achieving durable virus suppression in infected individuals. This success is based on two effects: additive or even synergistic virus inhibition and an increase in the genetic threshold...

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Bibliografski detalji
Izdano u:Antimicrob Agents Chemother
Glavni autori: Zhao, Na, Wang, Gang, Das, Atze T., Berkhout, Ben
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700367/
https://ncbi.nlm.nih.gov/pubmed/28893790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01486-17
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