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Pharmacological Inhibition of the Pseudomonas aeruginosa MvfR Quorum-Sensing System Interferes with Biofilm Formation and Potentiates Antibiotic-Mediated Biofilm Disruption

Pseudomonas aeruginosa biofilms contribute to its survival on biotic and abiotic surfaces and represent a major clinical threat due to their high tolerance to antibiotics. Therefore, the discovery of antibiofilm agents may hold great promise. We show that pharmacological inhibition of the P. aerugin...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Maura, Damien, Rahme, Laurence G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700327/
https://ncbi.nlm.nih.gov/pubmed/28923875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01362-17
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