AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice

OBJECTIVE: Hepatic steatosis is the first step leading to non-alcoholic fatty liver disease, which represents a major complication of obesity. Here, we show that MCT1 haploinsufficient mice resist to hepatic steatosis development when fed a high fat diet. They exhibit a reduced hepatic capacity to m...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Carneiro, Lionel, Asrih, Mohamed, Repond, Cendrine, Sempoux, Christine, Stehle, Jean-Christophe, Leloup, Corinne, Jornayvaz, François R., Pellerin, Luc
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699913/
https://ncbi.nlm.nih.gov/pubmed/29092796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.10.005
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