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AFM-based detection of glycocalyx degradation and endothelial stiffening in the db/db mouse model of diabetes

Degradation of the glycocalyx and stiffening of endothelium are important pathophysiological components of endothelial dysfunction. However, to our knowledge, these events have not been investigated in tandem in experimental diabetes. Here, the mechanical properties of the glycocalyx and endothelium...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Targosz-Korecka, Marta, Jaglarz, Magdalena, Malek-Zietek, Katarzyna E., Gregorius, Aleksandra, Zakrzewska, Agnieszka, Sitek, Barbara, Rajfur, Zenon, Chlopicki, Stefan, Szymonski, Marek
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698475/
https://ncbi.nlm.nih.gov/pubmed/29162916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16179-7
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