Endothelial Epas1 Deficiency Is Sufficient To Promote Parietal Epithelial Cell Activation and FSGS in Experimental Hypertension

FSGS, the most common primary glomerular disorder causing ESRD, is a complex disease that is only partially understood. Progressive sclerosis is a hallmark of FSGS, and genetic tracing studies have shown that parietal epithelial cells participate in the formation of sclerotic lesions. The loss of po...

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Veröffentlicht in:J Am Soc Nephrol
Hauptverfasser: Luque, Yosu, Lenoir, Olivia, Bonnin, Philippe, Hardy, Lise, Chipont, Anna, Placier, Sandrine, Vandermeersch, Sophie, Xu-Dubois, Yi-Chun, Robin, Blaise, Lazareth, Hélène, Souyri, Michèle, Guyonnet, Léa, Baudrie, Véronique, Camerer, Eric, Rondeau, Eric, Mesnard, Laurent, Tharaux, Pierre-Louis
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2017
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698059/
https://ncbi.nlm.nih.gov/pubmed/28928136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016090960
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