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The U(S)3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins

Earlier studies have shown that the d120 mutant of herpes simplex virus 1, which lacks both copies of the α4 gene, induces apoptosis in all cell lines tested. In some cell lines d120-induced apoptosis, manifested by the release of cytochrome c, activation of caspase 3, and fragmentation of cellular...

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Detalhes bibliográficos
Main Authors: Munger, Joshua, Roizman, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC56974/
https://ncbi.nlm.nih.gov/pubmed/11517326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.181344498
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