Intertwined Precursor Supply during Biosynthesis of the Catecholate–Hydroxamate Siderophores Qinichelins in Streptomyces sp. MBT76

[Image: see text] The explosive increase in genome sequencing and the advances in bioinformatic tools have revolutionized the rationale for natural product discovery from actinomycetes. In particular, this has revealed that actinomycete genomes contain numerous orphan gene clusters that have the pot...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Gubbens, Jacob, Wu, Changsheng, Zhu, Hua, Filippov, Dmitri V., Florea, Bogdan I., Rigali, Sébastien, Overkleeft, Herman S., van Wezel, Gilles P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2017
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696649/
https://ncbi.nlm.nih.gov/pubmed/28945067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00597
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