NOTCH1 is a mechanosensor in adult arteries

Endothelial cells transduce mechanical forces from blood flow into intracellular signals required for vascular homeostasis. Here we show that endothelial NOTCH1 is responsive to shear stress, and is necessary for the maintenance of junctional integrity, cell elongation, and suppression of proliferat...

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Udgivet i:Nat Commun
Main Authors: Mack, Julia J., Mosqueiro, Thiago S., Archer, Brian J., Jones, William M., Sunshine, Hannah, Faas, Guido C., Briot, Anais, Aragón, Raquel L., Su, Trent, Romay, Milagros C., McDonald, Austin I., Kuo, Cheng-Hsiang, Lizama, Carlos O., Lane, Timothy F., Zovein, Ann C., Fang, Yun, Tarling, Elizabeth J., de Aguiar Vallim, Thomas Q., Navab, Mohamad, Fogelman, Alan M., Bouchard, Louis S., Iruela-Arispe, M. Luisa
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696341/
https://ncbi.nlm.nih.gov/pubmed/29158473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01741-8
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