Accelerated podocyte detachment and progressive podocyte loss from glomeruli with age in Alport Syndrome

Podocyte depletion is a common mechanism driving progression in glomerular diseases. Alport Syndrome glomerulopathy, caused by defective α3α4α5 (IV) collagen heterotrimer production by podocytes, is associated with an increased rate of podocyte detachment detectable in urine and reduced glomerular p...

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Pubblicato in:Kidney Int
Autori principali: Ding, Fangrui, Wickman, Larysa, Wang, Su Q., Zhang, Yanqin, Wang, Fang, Afshinnia, Farsad, Hodgin, Jeffrey, Ding, Jie, Wiggins, Roger C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696060/
https://ncbi.nlm.nih.gov/pubmed/28754557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2017.05.017
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