Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

Glucagon is secreted from pancreatic α cells, and hypersecretion (hyperglucagonemia) contributes to diabetic hyperglycemia. Molecular heterogeneity in hyperglucagonemia is poorly investigated. By screening human plasma using high-resolution-proteomics, we identified several glucagon variants, among...

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Vydáno v:Cell Rep
Hlavní autoři: Wewer Albrechtsen, Nicolai J., Kuhre, Rune E., Hornburg, Daniel, Jensen, Christian Z., Hornum, Mads, Dirksen, Carsten, Svane, Maria, Gasbjerg, Lærke S., Jørgensen, Nils B., Gabe, Maria N., Balk-Møller, Emilie, Albrechtsen, Reidar, Winther-Sørensen, Marie, Galsgaard, Katrine D., Meissner, Felix, Jorsal, Tina, Lund, Asger, Vilsbøll, Tina, Eliasen, Rasmus, Bojsen-Møller, Kirstine N., Idorn, Thomas, Deacon, Carolyn F., Knop, Filip K., Rosenkilde, Mette M., Hartmann, Bolette, Feldt-Rasmussen, Bo, Mann, Matthias, Madsbad, Sten, Holst, Jens J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695911/
https://ncbi.nlm.nih.gov/pubmed/29117552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.10.034
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