Testis Determination Requires a Specific FGFR2 Isoform to Repress FOXL2

Male sex determination in mammals relies on sex determining region Y–mediated upregulation of sex determining region–box 9 (SOX9) expression in XY gonads, whereas Wnt family member (WNT)/R-spondin 1 signaling and forkhead box L2 (FOXL2) drive female sex determination in XX gonads. Fibroblast growth...

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Foilsithe in:Endocrinology
Main Authors: Bagheri-Fam, Stefan, Bird, Anthony D., Zhao, Liang, Ryan, Janelle M., Yong, Meiyun, Wilhelm, Dagmar, Koopman, Peter, Eswarakumar, Veraragavan P., Harley, Vincent R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Endocrine Society 2017
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695826/
https://ncbi.nlm.nih.gov/pubmed/28938467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2017-00674
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