Ehrlichia Activation of Wnt-PI3K-mTOR Signaling Inhibits Autolysosome Generation and Autophagic Destruction by the Mononuclear Phagocyte

In multicellular organisms, autophagy is induced as an innate defense mechanism. Notably, the obligate intracellular bacterium Ehrlichia chaffeensis resides in early endosome-like vacuoles and circumvents lysosomal fusion through an unknown mechanism, thereby avoiding destruction in the autophagolys...

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Detalhes bibliográficos
Publicado no:Infect Immun
Principais autores: Lina, Taslima T., Luo, Tian, Velayutham, Thangam-Sudha, Das, Seema, McBride, Jere W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695117/
https://ncbi.nlm.nih.gov/pubmed/28993455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00690-17
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