Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein

TP53 is the most frequently mutated gene in human cancer. Many mutant p53 proteins exert oncogenic gain-of-function (GOF) properties that contribute to metastasis, but the mechanisms mediating these functions remain poorly defined in vivo. To elucidate how mutant p53 GOF drives metastasis, we develo...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Pourebrahim, Rasoul, Zhang, Yun, Liu, Bin, Gao, Ruli, Xiong, Shunbin, Lin, Patrick P., McArthur, Mark J., Ostrowski, Michael C., Lozano, Guillermina
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695086/
https://ncbi.nlm.nih.gov/pubmed/29021240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.304972.117
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