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Hoxa2 Inhibits Bone Morphogenetic Protein Signaling during Osteogenic Differentiation of the Palatal Mesenchyme

Cleft palate is one of the most common congenital birth defects worldwide. The homeobox (Hox) family of genes are key regulators of embryogenesis, with Hoxa2 having a direct role in secondary palate development. Hoxa2(−/−) mice exhibit cleft palate; however, the cellular and molecular mechanisms lea...

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Détails bibliographiques
Publié dans:Front Physiol
Auteurs principaux: Iyyanar, Paul P. R., Nazarali, Adil J.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5694536/
https://ncbi.nlm.nih.gov/pubmed/29184513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00929
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