Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazines: Novel Antagonists for the Histamine H(3) and H(4) Receptors with Anti-inflammatory Potential

The histamine receptors (HRs) are traditional G protein-coupled receptors of extensive therapeutic interest. Recently, H(3)R and H(4)R subtypes have been targeted in drug discovery projects for inflammation, asthma, pain, cancer, Parkinson’s, and Alzheimer’s diseases, which includes searches for dua...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Main Authors: Corrêa, Michelle F., Barbosa, Álefe J. R., Teixeira, Larissa B., Duarte, Diego A., Simões, Sarah C., Parreiras-e-Silva, Lucas T., Balbino, Aleksandro M., Landgraf, Richardt G., Bouvier, Michel, Costa-Neto, Claudio M., Fernandes, João P. S.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5694482/
https://ncbi.nlm.nih.gov/pubmed/29184503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00825
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