Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis

Productive angiogenesis, a prerequisite for tumour growth, depends on the balanced release of angiogenic and angiostatic factors by different cell types within hypoxic tumours. Natural killer (NK) cells kill cancer cells and infiltrate hypoxic tumour areas. Cellular adaptation to low oxygen is media...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Krzywinska, Ewelina, Kantari-Mimoun, Chahrazade, Kerdiles, Yann, Sobecki, Michal, Isagawa, Takayuki, Gotthardt, Dagmar, Castells, Magali, Haubold, Johannes, Millien, Corinne, Viel, Thomas, Tavitian, Bertrand, Takeda, Norihiko, Fandrey, Joachim, Vivier, Eric, Sexl, Veronika, Stockmann, Christian
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5694012/
https://ncbi.nlm.nih.gov/pubmed/29150606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01599-w
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