Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis

Productive angiogenesis, a prerequisite for tumour growth, depends on the balanced release of angiogenic and angiostatic factors by different cell types within hypoxic tumours. Natural killer (NK) cells kill cancer cells and infiltrate hypoxic tumour areas. Cellular adaptation to low oxygen is media...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Krzywinska, Ewelina, Kantari-Mimoun, Chahrazade, Kerdiles, Yann, Sobecki, Michal, Isagawa, Takayuki, Gotthardt, Dagmar, Castells, Magali, Haubold, Johannes, Millien, Corinne, Viel, Thomas, Tavitian, Bertrand, Takeda, Norihiko, Fandrey, Joachim, Vivier, Eric, Sexl, Veronika, Stockmann, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5694012/
https://ncbi.nlm.nih.gov/pubmed/29150606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01599-w
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