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Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis
Productive angiogenesis, a prerequisite for tumour growth, depends on the balanced release of angiogenic and angiostatic factors by different cell types within hypoxic tumours. Natural killer (NK) cells kill cancer cells and infiltrate hypoxic tumour areas. Cellular adaptation to low oxygen is media...
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Veröffentlicht in: | Nat Commun |
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Hauptverfasser: | , , , , , , , , , , , , , , , |
Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
Nature Publishing Group UK
2017
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Schlagworte: | |
Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5694012/ https://ncbi.nlm.nih.gov/pubmed/29150606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01599-w |
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