Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis

Productive angiogenesis, a prerequisite for tumour growth, depends on the balanced release of angiogenic and angiostatic factors by different cell types within hypoxic tumours. Natural killer (NK) cells kill cancer cells and infiltrate hypoxic tumour areas. Cellular adaptation to low oxygen is media...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Krzywinska, Ewelina, Kantari-Mimoun, Chahrazade, Kerdiles, Yann, Sobecki, Michal, Isagawa, Takayuki, Gotthardt, Dagmar, Castells, Magali, Haubold, Johannes, Millien, Corinne, Viel, Thomas, Tavitian, Bertrand, Takeda, Norihiko, Fandrey, Joachim, Vivier, Eric, Sexl, Veronika, Stockmann, Christian
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5694012/
https://ncbi.nlm.nih.gov/pubmed/29150606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01599-w
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