FMNH(2)-dependent monooxygenases initiate catabolism of sulfonamides in Microbacterium sp. strain BR1 subsisting on sulfonamide antibiotics

We report a cluster of genes encoding two monooxygenases (SadA and SadB) and one FMN reductase (SadC) that enable Microbacterium sp. strain BR1 and other Actinomycetes to inactivate sulfonamide antibiotics. Our results show that SadA and SadC are responsible for the initial attack of sulfonamide mol...

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Publié dans:Sci Rep
Auteurs principaux: Ricken, Benjamin, Kolvenbach, Boris A., Bergesch, Christian, Benndorf, Dirk, Kroll, Kevin, Strnad, Hynek, Vlček, Čestmír, Adaixo, Ricardo, Hammes, Frederik, Shahgaldian, Patrick, Schäffer, Andreas, Kohler, Hans-Peter E., Corvini, Philippe F.-X.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693940/
https://ncbi.nlm.nih.gov/pubmed/29150672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16132-8
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