PDCT-04. SAFETY AND EFFICACY OF INTRAVENTRICULAR (131)I-LABELED MONOCLONAL ANTIBODY 8H9 TARGETING THE SURFACE GLYCOPROTEIN B7-H3 IN PATIENTS WITH CNS/LM DISEASE

BACKGROUND: Tumors metastasizing to the central nervous system (CNS) are associated with significant mortality. Intraventricular (131)I-labeled monoclonal antibody targeting tumor associated antigens may eradicate micrometastases. METHODS: We tested the toxicity and dosimetry of intraventricular (13...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Kramer, Kim, Kushner, Brian, Modak, Shakeel, Pandit-Taskar, Neeta, Tomlinson, Ursula, Donzelli, Maria, Wolden, Suzanne, Zanzonico, Pat, Humm, John, Haque, Sophia, Souweidane, Mark, Greenfield, Jeffrey, Basu, Ellen, Roberts, Stephen, Carrasquillo, Jorge, Lewis, Jason, Lyashchenko, Serge, Larson, Steven, Cheung, Nai-Kong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693087/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.748
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