EXTH-46. A PRECISION MEDICINE APPROACH TO TARGET EGFRvIII IN GBM: OSIMERTINIB (AZD9291) INHIBITS THE GROWTH OF EGFRvIII-POSITIVE GLIOBLASTOMA STEM CELLS AND INCREASES SURVIVAL OF MICE BEARING INTRACRANIAL EGFRvIII-POSITIVE GBM

Attempts to target EGFRvIII, which is present in over 20% of GBMs, with EGFR-tyrosine kinase inhibitors (EGFR-TKI) and vaccines have been unsuccessful. This failure appears to be due to two main reasons: 1) the selected EGFR-TKI did not penetrate the brain well; and 2) the heterogeneity of EGFRvIII...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Kwatra, Madan, Nanni, Cory, Roberts, Callie, Kwatra, Shawn, Gilbert, Mark R, Lesser, Glenn J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693080/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.338
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