ACTR-33. A PHASE I DOSE ESCALATION AND CENTRAL NERVOUS SYSTEM (CNS) PHARMACOKINETIC STUDY OF PULSATILE AFATINIB IN PATIENTS WITH BRAIN CANCER

Patients with primary brain cancer or brain metastases represent a population with a large unmet medical need. The critical premise behind our investigation into pulse dosing of growth factor inhibitors for brain cancer is that current treatment is limited by drug penetration into the central nervou...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Juarez, Tiffany, Boucher, Najee, Heng, Annie, Gill, Jaya, Nguyen, Minhdan, Truong, Judy, Saria, Marlon, Achrol, Achal, Barkhoudarian, Garni, Kelly, Daniel, Kesari, Santosh
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692747/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.026
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