Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis

Elimination of filariasis requires a macrofilaricide treatment that can be delivered within a 7-day period. Here we have identified a synergy between the anthelmintic albendazole (ABZ) and drugs depleting the filarial endosymbiont Wolbachia, a proven macrofilaricide target, which reduces treatment f...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Turner, Joseph D., Sharma, Raman, Al Jayoussi, Ghaith, Tyrer, Hayley E., Gamble, Joanne, Hayward, Laura, Priestley, Richard S., Murphy, Emma A., Davies, Jill, Waterhouse, David, Cook, Darren A. N., Clare, Rachel H., Cassidy, Andrew, Steven, Andrew, Johnston, Kelly L., McCall, John, Ford, Louise, Hemingway, Janet, Ward, Stephen A., Taylor, Mark J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692564/
https://ncbi.nlm.nih.gov/pubmed/29078351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710845114
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