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EXTH-54. METFORMIN ACTS SYNERGISTICALLY WITH GALLIUM MALTOLATE TO INHIBIT THE PROLIFERATION OF GLIOBLASTOMA CELLS BY ACTION ON MITOCHONDRIAL FUNCTION

BACKGROUND: There is a vital need for new therapeutics to treat glioblastoma (GBM). Recently, we showed that gallium maltolate (GaM) inhibits the iron-dependent growth of GBM in vitro and in vivo. Here, we investigated whether metformin, an antidiabetic drug that can enter the brain, could potentiat...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Alhajala, Hisham S, Al-Gizawiy, Mona M, Schmainda, Kathleen M, Chitambar, Christopher R
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692387/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.346
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