ANGI-07. OXIDIZED MIF DRIVES GLIOBLASTOMA CELL INVASION DURING BEVACIZUMAB RESISTANCE THROUGH UNIQUE SIGNALING MECHANISMS

INTRODUCTION: Bevacizumab, an anti-VEGF monoclonal antibody, initially showed promising results as an anti-angiogenic therapy in treatment of glioblastoma. However, further trials demonstrated lack of durable efficacy and no improved overall survival, with resistant tumors displaying increased invas...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Hoffman, Daniel, Nguyen, Alan, Jahangiri, Arman, Flanigan, Patrick M, Lin, Jung Ming George, Kumar, Sanjay, Aghi, Manish
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692378/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.086
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