CBIO-12. GTP METABOLIC SWITCH LEADS TO NUCLEOLAR TRANSFORMATION AND MALIGNANT GROWTH OF GLIOBLASTOMA

Nucleolar mass is frequently increased in malignant cells, pointing to a prominent role for aberrant rRNA transcription in highly anabolic cells. ATP and GTP, fundamental energy currencies and building blocks for DNA and RNA, are synthesized by the energy-efficient salvage pathway and energy-demandi...

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Pubblicato in:Neuro Oncol
Autori principali: Satoshi, Kofuji, Hirayama, Akiyoshi, Sakamoto, Naoya, Sumita, Kazutaka, Yoshino, Hirofumi, Warren, Mikako, Kawaguchi, Risa, Ozawa, Tatsuya, Onishi, Nobuyuki, Wolfe, Kara, Okumura, Koichi, Ramkissoon, Annmarie, Chow, Lionel M L, Malhotra, Akshiv, Terakawa, Jumpei, Daikoku, Takiko, Wise-Draper, Trisha, Majd, Nazanin, Kofuji, Kaori, Sasaki, Mika, Mori, Masaru, Anastasiou, Dimitrios, Wakimoto, Hiroaki, Bierhoff, Holger, Horbinski, Craig M, Yasui, Wataru, Saya, Hideyuki, Soga, Tomoyoshi, Holland, Eric, Grummt, Ingrid, Mischel, Paul, Sasaki, Atsuo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Abstracts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692196/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.134
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