IMMU-63. OVERCOMING GLIOBLASTOMA RESISTANCE TO IMMUNE CHECKPOINT BLOCKADE VIA RNA-LOADED NANOPARTICLES

BACKGROUND: In a randomized phase III study for recurrent glioblastoma (GBM), checkpoint inhibition with nivolumab failed to improve overall survival outcomes. GBM immune escape through loss of MHC class expression juxtaposed to an immunoregulatory milieu, both local and systemic, remain significant...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Sayour, Elias, Grippin, Adam, Mendez-Gomez, Hector, De Leon, Gabriel, Mitchell, Duane
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
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Abstracts
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692051/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.520
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