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IMMU-63. OVERCOMING GLIOBLASTOMA RESISTANCE TO IMMUNE CHECKPOINT BLOCKADE VIA RNA-LOADED NANOPARTICLES
BACKGROUND: In a randomized phase III study for recurrent glioblastoma (GBM), checkpoint inhibition with nivolumab failed to improve overall survival outcomes. GBM immune escape through loss of MHC class expression juxtaposed to an immunoregulatory milieu, both local and systemic, remain significant...
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| Publicat a: | Neuro Oncol |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692051/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.520 |
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