ATIM-12. PHASE 2 STUDY TO EVALUATE THE CLINICAL EFFICACY AND SAFETY OF MEDI4736 (DURVALUMAB [DUR]) IN PATIENTS WITH BEVACIZUMAB (BEV)-REFRACTORY RECURRENT GLIOBLASTOMA (GBM)

BACKGROUND: GBM patients who progress on BEV, an approved angiogenesis inhibitor for recurrent GBM, have a dismal outcome with a median survival of < 6 months. DUR is a human IgG1 monoclonal Ab against PD-L1. METHODS: This ongoing Phase 2 open-label study (NCT02336165) evaluates safety and effica...

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Publicado no:Neuro Oncol
Main Authors: Reardon, David, Kaley, Thomas, Dietrich, Jorg, Clarke, Jennifer L, Dunn, Gavin P, Lim, Michael, Cloughesy, Timothy, Gan, Hui K, Park, Andrew, Schwarzenberger, Paul, Ricciardi, Toni, Macri, Mary, Ryan, Aileen, Venhaus, Ralph
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692026/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.108
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