EXTH-80. ENHANCED THERAPEUTIC RESPONSE IN MURINE MEDULLOBLASTOMA TUMOR MODEL USING ADENANTHIN AND TRANSIENT MODULATION OF THE BLOOD-BRAIN BARRIER WITH CADHERIN PEPTIDE

BACKGROUND: Peroxiredoxin1 (PRDX1) is overexpressed in medulloblastoma (MBL) causing resistance to therapy. Adenanthin (PRDX1 inhibitor) had been validated as a therapeutic target in MBL. However, adenanthin does not cross the blood-brain barrier (BBB). The objective of this study was to examine the...

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Publicat a:Neuro Oncol
Autors principals: On, Ngoc H, Babu, Sajesh, Omar, Refaat, Alrushaid, Samaa, Wang, Yan, Pu, Jian-Xin, Sun, Han-Dong, Davies, Neil, Siahaan, Teruna, Issaivanan, Magimairajan, Miller, Donald W
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
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Abstracts
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691946/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.370
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