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EXTH-80. ENHANCED THERAPEUTIC RESPONSE IN MURINE MEDULLOBLASTOMA TUMOR MODEL USING ADENANTHIN AND TRANSIENT MODULATION OF THE BLOOD-BRAIN BARRIER WITH CADHERIN PEPTIDE
BACKGROUND: Peroxiredoxin1 (PRDX1) is overexpressed in medulloblastoma (MBL) causing resistance to therapy. Adenanthin (PRDX1 inhibitor) had been validated as a therapeutic target in MBL. However, adenanthin does not cross the blood-brain barrier (BBB). The objective of this study was to examine the...
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| Publicat a: | Neuro Oncol |
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| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5691946/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.370 |
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