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Mutation of a Conserved Nuclear Export Sequence in Chikungunya Virus Capsid Protein Disrupts Host Cell Nuclear Import

Transmitted by mosquitoes; chikungunya virus (CHIKV) is responsible for frequent outbreaks of arthritic disease in humans. CHIKV is an arthritogenic alphavirus of the Togaviridae family. Capsid protein, a structural protein encoded by the CHIKV RNA genome, is able to translocate to the host cell nuc...

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Bibliografiske detaljer
Udgivet i:Viruses
Main Authors: Jacobs, Susan C., Taylor, Adam, Herrero, Lara J., Mahalingam, Suresh, Fazakerley, John K.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691657/
https://ncbi.nlm.nih.gov/pubmed/29053568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v9100306
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