Concomitant Loss of the Glyoxalase System and Glycolysis Makes the Uncultured Pathogen “Candidatus Liberibacter asiaticus” an Energy Scavenger

Methylglyoxal (MG) is a cytotoxic, nonenzymatic by-product of glycolysis that readily glycates proteins and DNA, resulting in carbonyl stress. Glyoxalase I and II (GloA and GloB) sequentially convert MG into d-lactic acid using glutathione (GSH) as a cofactor. The glyoxalase system is essential for...

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Vydáno v:Appl Environ Microbiol
Hlavní autoři: Jain, Mukesh, Munoz-Bodnar, Alejandra, Gabriel, Dean W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Plant Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691416/
https://ncbi.nlm.nih.gov/pubmed/28939611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01670-17
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