Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation

The ‘acidic patch’ is a highly electronegative cleft on the histone H2A–H2B dimer in the nucleosome. It is a fundamental motif for protein binding and chromatin dynamics, but the cellular impact of targeting this potentially therapeutic site with exogenous molecules remains unclear. Here, we charact...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Davey, Gabriela E., Adhireksan, Zenita, Ma, Zhujun, Riedel, Tina, Sharma, Deepti, Padavattan, Sivaraman, Rhodes, Daniela, Ludwig, Alexander, Sandin, Sara, Murray, Benjamin S., Dyson, Paul J., Davey, Curt A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691193/
https://ncbi.nlm.nih.gov/pubmed/29146919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01680-4
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados