PD-1 expression in head and neck squamous cell carcinomas derives primarily from functionally anergic CD4+ TILs in the presence of PD-L1+ TAMs

Oral tongue squamous cell carcinoma (OTSCC) is the most common oral cavity tumor. In this study, we examined the basis for the activity of PD-1-based immune checkpoint therapy that is being explored widely in head and neck cancers. Using multispectral imaging, we systematically investigated the OTSC...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Mattox, Austin K., Lee, Jina, Westra, William H., Pierce, Robert H., Ghossein, Ronald, Faquin, William C., Diefenbach, Thomas J., Morris, Luc G., Lin, Derrick T., Wirth, Lori J., Lefranc-Torres, Armida, Ishida, Eiichi, Chakravarty, Patrick D., Johnson, Lauren, Zeng, Yang C., Chen, Huabiao, Poznansky, Mark C., Iyengar, Neil M., Pai, Sara I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690870/
https://ncbi.nlm.nih.gov/pubmed/28947422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-3453
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