A dynamic ribosomal biogenesis response is not required for IGF-1–mediated hypertrophy of human primary myotubes

Increased ribosomal DNA transcription has been proposed to limit muscle protein synthesis, making ribosome biogenesis central to skeletal muscle hypertrophy. We examined the relationship between ribosomal RNA (rRNA) production and IGF-1–mediated myotube hypertrophy in vitro. Primary skeletal myotube...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Crossland, Hannah, Timmons, James A., Atherton, Philip J.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690393/
https://ncbi.nlm.nih.gov/pubmed/28774889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700329R
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