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In silico and in vitro identification of inhibitory activities of sorafenib on histone deacetylases in hepatocellular carcinoma cells

Although sorafenib has been approved for treating hepatocellular carcinoma (HCC), clinical results are not satisfactory. Polypharmacology (one drug with multiple molecular targets) is viewed as an attractive strategy for identifying novel mechanisms of a drug and then rationally designing more-effec...

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Pubblicato in:Oncotarget
Autori principali: Liu, Tsang-Pai, Hong, Yi-Han, Yang, Pei-Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689675/
https://ncbi.nlm.nih.gov/pubmed/29156785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21030
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