TP53 Mutation Does Not Confer a Poor Outcome in Adult ALL Treated with Frontline Hyper-CVAD-based Regimens

BACKGROUND: TP53 mutations are uncommon in adult acute lymphoblastic leukemia (ALL) and predict poor outcome. METHODS: We performed TP53 mutation analysis in 164 newly diagnosed adult ALL patients using a combination of targeted amplicon-based next-generation sequencing and Sanger sequencing. RESULT...

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Vydáno v:Cancer
Hlavní autoři: Kanagal-Shamanna, Rashmi, Jain, Preetesh, Takahashi, Koichi, Short, Nicholas J., Tang, Guilin, Issa, Ghayas C., Ravandi, Farhad, Garcia-Manero, Guillermo, Yin, Cameron C., Luthra, Rajyalakshmi, Patel, Keyur P., Khoury, Joseph D., Montalban-Bravo, Guillermo, Sasaki, Koji, Kadia, Tapan M., Borthakur, Gautam, Konopleva, Marina, Jain, Nitin, Garris, Rebecca, Pierce, Sherry, Wierda, William, Estrov, Zeev, Cortes, Jorge, O’Brien, Susan, Kantarjian, Hagop, Jabbour, Elias
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689475/
https://ncbi.nlm.nih.gov/pubmed/28608976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30810
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