The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD

The natural product carolacton is a macrolide keto-carboxylic acid produced by the myxobacterium Sorangium cellulosum, and was originally described as an antibacterial compound. Here we show that carolacton targets FolD, a key enzyme from the folate-dependent C1 metabolism. We characterize the inter...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Fu, Chengzhang, Sikandar, Asfandyar, Donner, Jannik, Zaburannyi, Nestor, Herrmann, Jennifer, Reck, Michael, Wagner-Döbler, Irene, Koehnke, Jesko, Müller, Rolf
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688156/
https://ncbi.nlm.nih.gov/pubmed/29142318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01671-5
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