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The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
The natural product carolacton is a macrolide keto-carboxylic acid produced by the myxobacterium Sorangium cellulosum, and was originally described as an antibacterial compound. Here we show that carolacton targets FolD, a key enzyme from the folate-dependent C1 metabolism. We characterize the inter...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5688156/ https://ncbi.nlm.nih.gov/pubmed/29142318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01671-5 |
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