Proteotoxicity in cardiac amyloidosis: amyloidogenic light chains affect the levels of intracellular proteins in human heart cells

AL amyloidosis is characterized by widespread deposition of immunoglobulin light chains (LCs) as amyloid fibrils. Cardiac involvement is frequent and leads to life-threatening cardiomyopathy. Besides the tissue alteration caused by fibrils, clinical and experimental evidence indicates that cardiac d...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Imperlini, Esther, Gnecchi, Massimiliano, Rognoni, Paola, Sabidò, Eduard, Ciuffreda, Maria Chiara, Palladini, Giovanni, Espadas, Guadalupe, Mancuso, Francesco Mattia, Bozzola, Margherita, Malpasso, Giuseppe, Valentini, Veronica, Palladini, Giuseppina, Orrù, Stefania, Ferraro, Giovanni, Milani, Paolo, Perlini, Stefano, Salvatore, Francesco, Merlini, Giampaolo, Lavatelli, Francesca
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688098/
https://ncbi.nlm.nih.gov/pubmed/29142197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15424-3
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