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Developmental plasticity shapes synaptic phenotypes of autism-associated neuroligin-3 mutations in the calyx of Held

Neuroligins are postsynaptic cell-adhesion molecules that bind to presynaptic neurexins. Mutations in neuroligin-3 predispose to autism, but how such mutations affect synaptic function remains incompletely understood. Here we systematically examined the effect of three autism-associated mutations, t...

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Dettagli Bibliografici
Pubblicato in:Mol Psychiatry
Autori principali: Zhang, B, Seigneur, E, Wei, P, Gokce, O, Morgan, J, Südhof, TC
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687809/
https://ncbi.nlm.nih.gov/pubmed/27725662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2016.157
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