Soluble glycoprotein VI, a specific marker of platelet activation is increased in the plasma of subjects with seropositive rheumatoid arthritis

OBJECTIVES: Anti-citrullinated protein antibodies (ACPA) have been shown to cause platelet activation in vitro, through the low-affinity immunoglobulin G (IgG) receptor (FcγRIIa) on platelets. Platelet activation via engagement of FcγRIIa results in proteolytic cleavage and shedding of platelet spec...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Stack, John R., Madigan, Anne, Helbert, Laura, Dunne, Eimear, Gardiner, Elizabeth E., Andrews, Robert K., Finan, Roisin, Smyth, Elizabeth, Kenny, Dermot, McCarthy, Geraldine M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687752/
https://ncbi.nlm.nih.gov/pubmed/29141000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188027
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