Safety and preclinical efficacy of aerosol pioglitazone on lung adenoma prevention in A/J mice

Pioglitazone is a PPARγ agonist commonly prescribed for the clinical treatment of diabetes. We sought to expand its use to lung cancer prevention in a benzo[a]pyrene (B[a]P) mouse model with direct lung delivery via inhalation. Initially we conducted inhalational toxicity experiments with 0, 15, 50,...

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Gepubliceerd in:Cancer Prev Res (Phila)
Hoofdauteurs: Seabloom, Donna E., Galbraith, Arthur R., Haynes, Anna M., Antonides, Jennifer D., Wuertz, Beverly R., Miller, Wendy A., Miller, Kimberly A., Steele, Vernon E., Suen, Chen S., O’Sullivan, M. Gerard, Ondrey, Frank G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687250/
https://ncbi.nlm.nih.gov/pubmed/27993834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-16-0174
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